In 2019,Environmental Science & Technology included an article by Ji, Chenyang; Shen, Chao; Zhou, Yixi; Zhu, Kongyang; Sun, Zhe; Zuo, Zhenghong; Zhao, Meirong. Related Products of 6825-20-3. The article was titled 《AhR Agonist Activity Confirmation of Polyhalogenated Carbazoles (PHCZs) Using an Integration of in Vitro, in Vivo, and in Silico Models》. The information in the text is summarized as follows:
Polyhalogenated carbazoles (PHCZs) are a kind of rising environmental pollutants that have been reported to pose high risk to human beings and natural environment. PHCZs are of a similar mol. structure with of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and exhibited some dioxin-like toxicity. Dioxin-like compounds (DLCs) are required to be banned by the Stockholm Convention due to their potential adverse impacts to the environment and public health. However, few efforts have been done towards the regulation of PHCZs. Herein, we initiated multi-models to systematically determine and validate the dioxin-like effects of PHCZs in a large scale. Transgenic zebrafish line-Tg(cyp1a-12DRE:EGFP) and stably transfected HepG2 cell line with luciferase reporter plasmids were used to screen and evaluate the aryl hydrocarbon receptor (AhR) agonist effects of the target PHCZs, which were then verified by application of mol. docking and expression levels of AhR downstream genes. Results of the two bioassays showed that most of the tested PHCZs could pose dioxin-like AhR agonist effects, change the expression levels of AhR downstream genes, and interact with AhR in accordance with TCDD. In summary, data presented here can help to guide the safe use and regulation of PHCZs. The results came from multiple reactions, including the reaction of 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Related Products of 6825-20-3)
3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a reagent in the synthesis of P7C3-A20 which is a potent neuroprotective agent. And it has been used in the preparation of N-(2-hydroxyethyl)-3,6-dibromocarbazole.Related Products of 6825-20-3
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary