The author of 《Determination of carbazole and halogenated carbazoles in human serum samples using GC-MS/MS》 were Fang, Li; Qiu, Fengmei; Li, Ying; Wang, Shizhong; DeGuzman, Josephine; Wang, Jun; She, Jianwen. And the article was published in Ecotoxicology and Environmental Safety in 2019. Computed Properties of C12H7Br2N The author mentioned the following in the article:
Carbazole and halogenated carbazoles have been widely detected throughout the environment in soil, river deposits, and lake sediments. Human exposure to these compounds may occur through inhalation, drinking water, dietary intake and/or skin contact, and exposure levels in the body may be evaluated by measuring them in serum or blood. This paper reports the method development and validation for the anal. of carbazole and 11 halogenated carbazoles in human blood and/or serum samples. A small sample size of 100μL of blood or serum was employed for the anal. The samples were prepared through salting-out liquid-liquid extraction (LLE) by using hexane/ethyl acetate (4:1, volume/volume) as the extraction solvent and aqueous MgSO4 (37.5 wt%) as the salting-out regent, resp. Sample anal. was performed using gas-chromatog. (GC) coupled with a tandem mass spectrometer (MS/MS) in an electron impact (EI) mode. The developed method demonstrated low detection limits in the range of 0.02-0.27 ng/mL, intra-day accuracy ranging from 81.2% to 125%, and inter-day accuracy from 91.0% to 117%. The intra- and inter-day precisions, calculated by relative standard deviations (RSDs), were in the ranges of 1.0-16.0% and 1.8-16.4%, resp. The developed method was applied to the anal. of 50 human serum samples collected from pregnant women in Southern California in 2012. Low concentrations of carbazole were measured in 18 samples, while halogenated carbazoles were not detected in any of the samples. In the experimental materials used by the author, we found 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Computed Properties of C12H7Br2N)
3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used as a reagent in the synthesis of P7C3-A20 which is a potent neuroprotective agent.Computed Properties of C12H7Br2N
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary