Koshino, Seitaro; Taniguchi, Tohru; Monde, Kenji; Kwon, Eunsang; Hayashi, Yujiro published their research in Chemistry – A European Journal in 2021. The article was titled 《Enantiodivergent One-Pot Synthesis of Axially Chiral Biaryls Using Organocatalyst-Mediated Enantioselective Domino Reaction and Central-to-Axial Chirality Conversion》.Product Details of 7073-94-1 The article contains the following contents:
Enantiodivergent one-pot synthesis of biaryls I (Ar = 2-O2NC6H4, 2-IC6H4, 1-naphthyl, etc.; R = H, 6-Br, 7-Br) from aryl aldehydes II and cinnamaldehydes ArCH:CHCHO has been developed using a catalytic amount of a single chiral source. A domino organocatalyst-mediated enantioselective Michael reaction and aldol condensation provided centrally chiral dihydronaphthalenes with excellent enantioselectivity, from which an enantiodivergent chirality conversion from central-to-axial chirality was achieved. Both enantiomers of biaryls I were obtained with excellent enantioselectivity. All transformations can be conducted in a single reaction vessel. A plausible reaction mechanism for the enantiodivergence is proposed. The results came from multiple reactions, including the reaction of 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Product Details of 7073-94-1)
1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. Product Details of 7073-94-1
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary