《Design, synthesis and biological activity evaluation of novel carbazole-benzylpiperidine hybrids as potential anti Alzheimer agents》 was published in Journal of Molecular Structure in 2020. These research results belong to Sadeghian, Batool; Sakhteman, Amirhossein; Faghih, Zeinab; Nadri, Hamid; Edraki, Najmeh; Iraji, Aida; Sadeghian, Issa; Rezaei, Zahra. SDS of cas: 6825-20-3 The article mentions the following:
In this study a series of novel carbazole-benzylpiperidine hybrids was designed, synthesized and evaluated as acetylcholinesterase and butyrylcholinesterase inhibitors. Moreover, some of these compounds were evaluated for anti β-secretase (BACE1) activity and metal chelation properties. Among the synthesized compounds, I (n = 2) (IC50 = 16.5μM for AChE and IC50 = 0.59μM for BuChE) and I (n = 3) (IC50 = 26.5μM for AChE and IC50 = 0.18μM for BuChE) showed highest inhibitory activity against acetylcholinesterase and butyrylcholinesterase. Furthermore, these compounds I (n = 2, 3) displayed interaction with Zn2+ ion and compound I (n = 3) showed moderate inhibitory activity against BACE1 (24.5% at 50μM). Kinetic and docking studies exhibited that these compounds likely acts as non-competitive inhibitors, able to interact with the catalytic active site (CAS) and peripheral anionic site (PAS) of acetylcholinesterase simultaneously. The experimental process involved the reaction of 3,6-Dibromo-9H-carbazole(cas: 6825-20-3SDS of cas: 6825-20-3)
3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a reagent in the synthesis of P7C3-A20 which is a potent neuroprotective agent. And it has been used in the preparation of N-(2-hydroxyethyl)-3,6-dibromocarbazole.SDS of cas: 6825-20-3
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary