In 2022,Andrews, David M.; Cartic, Sharon; Cosulich, Sabina; Divecha, Nullin; Faulder, Paul; Flemington, Vikki; Kern, Oliver; Kettle, Jason G.; MacDonald, Ellen; McKelvie, Jennifer; Pike, Kurt G.; Roberts, Bryan; Rowlinson, Rachel; Smith, James M.; Stockley, Martin; Swarbrick, Martin E.; Treinies, Iris; Waring, Michael J. published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Identification and optimization of a novel series of selective PIP5K inhibitors》.Safety of 3,5-Dibromoaniline The author mentioned the following in the article:
Phosphatidyl inositol (4,5)-bisphosphate (PI(4,5)P2) plays several key roles in human biol. and the lipid kinase that produces PI(4,5)P2, PIP5K, has been hypothesized to provide a potential therapeutic target of interest in the treatment of cancers. To better understand and explore the role of PIP5K in human cancers there remains an urgent need for potent and specific PIP5K inhibitor mols. Following a high throughput screen of the AstraZeneca collection, a novel, moderately potent and selective inhibitor of PIP5K, 1, was discovered. Detailed exploration of the SAR for this novel scaffold resulted in the considerable optimization of both potency for PIP5K, and selectivity over the closely related kinase PI3Kα, as well as identifying several opportunities for the continued optimization of drug-like properties. As a result, several high quality in vitro tool compounds were identified (8, 20 and 25) that demonstrate the desired biochem. and cellular profiles required to aid better understanding of this complex area of biol.3,5-Dibromoaniline(cas: 626-40-4Safety of 3,5-Dibromoaniline) was used in this study.
3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Safety of 3,5-Dibromoaniline
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary