《Design, synthesis, and biological evaluation of 3-amino-2-oxazolidinone derivatives as potent quorum-sensing inhibitors of Pseudomonas aeruginosa PAO1》 was published in European Journal of Medicinal Chemistry in 2020. These research results belong to Jiang, Kai; Yan, Xinlin; Yu, Jiahao; Xiao, Zijian; Wu, Hao; Zhao, Meihua; Yue, Yuandong; Zhou, Xiaoping; Xiao, Junhai; Lin, Feng. Application of 2969-81-5 The article mentions the following:
A series of 3-amino-2-oxazolidinone compounds (I) [R = 4-FC6H4, 4-ClC6H4, 4-NO2C6H4, etc.; X = O, S; n = 1,2,3,4] was designed and synthesized using ZS-12 as the lead compound Compounds I were screened for inhibitory activities against QS using C. violaceum CV026 as a reporter strain. Some of the compounds I showed good activities (IC50 range 3.69-63.58μM) and compound I [R = 4-BrC6H4; X = O; n = 1] inhibition was the most significant (IC50= 3.686 ± 0.5790μM) against biofilm formation and virulence factors determination of P. aeruginosa PAO1. In vitro, compound I [R = 4-BrC6H4; X = O; n = 1] significantly inhibited the formation of PAO1 biofilm (range 42.98%-17.67%), the production of virulence factors (pyocyanin, elastase, rhamnolipid and protease) and bacterial motility. Moreover, the combination of compound I [R = 4-BrC6H4; X = O; n = 1] with an antibiotic (meropenem trihydrate) could significantly improve the antibiotic susceptibility of biofilm P. aeruginosa PAO1 cells. In vivo, compound I [R = 4-BrC6H4; X = O; n = 1] significantly prolonged the lifespan of wildtype Caenorhabditis elegans N2 infected by P. aeruginosa PAO1. In conclusion, compound I [R = 4-BrC6H4; X = O; n = 1] was a candidate agent for antibiotic-resistant P. aeruginosa PAO1 and provided a method for finding new antibacterial drugs. The experimental process involved the reaction of Ethyl 4-bromobutyrate(cas: 2969-81-5Application of 2969-81-5)
Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Application of 2969-81-5
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary