In 2016,Isenegger, Patrick G.; Baechle, Florian; Pfaltz, Andreas published 《Asymmetric Morita-Baylis-Hillman reaction: catalyst development and mechanistic insights based on mass spectrometric back-reaction screening》.Chemistry – A European Journal published the findings.Category: bromides-buliding-blocks The information in the text is summarized as follows:
An efficient protocol for the evaluation of catalysts for the asym. Morita-Baylis-Hillman (MBH) reaction was developed. By mass spectrometric back-reaction screening of quasi-enantiomeric MBH products, an efficient bifunctional phosphine catalyst was identified that outperforms literature-known catalysts in the MBH reaction of Me acrylate with aldehydes. The close match between the selectivities measured for the forward and back reaction and kinetic measurements provided strong evidence that the aldol step and not the subsequent proton transfer is rate- and enantioselectivity-determining In the experiment, the researchers used many compounds, for example, 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Category: bromides-buliding-blocks)
1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Category: bromides-buliding-blocks In contrast, terrestrial plants account only for a few bromine-containing compounds.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary