Synthetic Route of C7H5BrO2In 2019 ,《Design and synthesis of new norfloxacin-1,3,4-oxadiazole hybrids as antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA)》 was published in European Journal of Pharmaceutical Sciences. The article was written by Guo, Yong; Xu, Ting; Bao, Chongnan; Liu, Zhiyan; Fan, Jiangping; Yang, Ruige; Qin, Shangshang. The article contains the following contents:
Toward the search of new antibacterial agents to control methicillin-resistant Staphylococcus aureus (MRSA), aclass of new norfloxacin-1,3,4-oxadiazole hybrids were designed and synthesized. Antibacterial activities againstdrug-sensitive bacteria S. aureus and clin. drug resistant isolates of MRSA were evaluated. Compound 5k exhibited excellent antibacterial activities against S. aureus (MIC: 2μg/mL) and MRSA1-3 (MIC: 0.25-1μg/mL). The time-kill kinetics demonstrated that compound 5k had an advantage over commonly used antibiotics vancomycin in killing S. aureus and MRSA. Moreover, compound 5k could inhibit the bacteria and destroy their membranes in a short time and showed very low cytotoxicity to NRK-52E cells. Some interesting structureactivity relationships (SARs) were also discussed. These results indicated that these norfloxacin-1,3,4-oxadiazole hybrids could be further developed into new antibacterial agents against MRSA. After reading the article, we found that the author used 4-Bromobenzoic acid(cas: 586-76-5Synthetic Route of C7H5BrO2)
4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Synthetic Route of C7H5BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary