2695-48-9, name is 8-Bromo-1-octene, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 8-Bromo-1-octene
THF (21 mL) was coolecd to -50 C, n-BuLi (2.5 M, 10.3 mL) was added dropwise. After addition, i-Pr2 H (2.6 g, 25.7 mmol, 3.6 mL) was added to the solution dropwise. After addition, the solution was stirred at -50 C for 0.5 hr. Then the solution was warmed up to -30 C, and a solution of compound 14A (1.4 g, 10.3 mmol, 1.4 mL) in THF (10 mL) and Heptane (10 mL) was added. Then a solution of compound 14B (2.4 g, 12.4 mmol, 2.1 mL) in THF (8 mL) was added. The reaction was stirred at -30 C for lhr. The mixture was quenched with H20 (100 mL). The organics were separated and extracted with H20 (50 mL x 2). The aqueous phase was acidified with IN HCl to pH ~ 2 and then extracted with EtOAc (100 mL x 2). The organics were collected, dried with Na2S04, filtered and concentrated to afford compound 14C (4.4 g, crude) as light yellow oil, which was used directly for the next step without further purification. 1H NMR (CDCI3, 400 MHz): delta 7.90 – 7.88 (m, 1H), 7.34 – 7.31 (m, 1H), 7.15 – 7.09 (m, 2H), 5.72 – 5.63 (m, 1H), 4.87 – 4.76 (m, 2H), 2.90 – 2.86 (m, 2H), 1.92 – 1.87 (m, 2H), 1.50 – 1.47 (m, 2H), 1.26 – 1.14 (m, 8H).
The synthetic route of 2695-48-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BLADE THERAPEUTICS, INC.; BUCKMAN, Brad, Owen; YUAN, Shendong; MA, Jingyuan; EMAYAN, Kumaraswamy; ADLER, Marc; (327 pag.)WO2018/9417; (2018); A1;,
Bromide – Wikipedia,
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