Amrutkar, Rakesh Devidas; Ranawat, Mahendra Sing published the artcile< Microwave Assisted Synthesis and Molecular Docking Studies of Some 4- (3H)-quinazolinone Derivatives as Inhibitors of Human Gamma- Aminobutyric Acid Receptor, the GABA (A)R-BETA3 Homopentamer>, Related Products of 20776-50-5, the main research area is quinazolinone green chem mol docking GABA inhibitor; Anthranilic acid; GABA-A receptor; NMR.; anticonvulsant activities; green chemistry; quinazolin-4-(3H) one.
The Microwave irradiation for the synthesis of the quinazolinone compounds I [R = H, Br; R1 = NH2, 4-H3CC6H4, 4-O2NC6H4, etc.] offers a reduction in reaction time, operation simplicity, cleaner reaction, easy work-up and improved yields. The procedure clearly highlights the advantages of green chem. The data reported in this article may be helpful for the medicinal chemists who are working in this area. The protein-ligand interaction plays a significant role in structural based drug designing. In the present work, the ligand, 2, 3-disubstituted quinazolinone docked with the proteins that are used as the target for GABA-A receptor.
Medicinal Chemistry (Sharjah, United Arab Emirates) published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Related Products of 20776-50-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary