Wang, Shengzheng; Chen, Shuqiang; Guo, Zhongjie; He, Shipeng; Zhang, Fan; Liu, Xueying; Chen, Weiping; Zhang, Shengyong; Sheng, Chunquan published the artcile< Synthesis of spiro-tetrahydrothiopyran-oxindoles by Michael-aldol cascade reactions: discovery of potential P53-MDM2 inhibitors with good antitumor activity>, Related Products of 3893-18-3, the main research area is spiro tetrahydrothiopyran oxindole diastereoselective preparation SAR antitumor; indolinone unsaturated aldehyde Michael aldol cascade proline catalyst.
Using proline as a catalyst, an organocatalytic Michael-aldol cascade reaction was developed for the synthesis of spiro-tetrahydrothiopyran oxindoles I [R1 = H, F, Me, Cl, Br; R2 = 2-furyl, Ph, 4-BrC6H4, etc.; R3 = Et, n-Pr, Ph, etc.] from indolinones and α,β-unsaturated aldehydes. The highly functionalized scaffold was assembled in moderate to good yields (51-78%) and excellent diastereoselectivities (>20 : 1 dr). Interestingly, the oxindoles I displayed moderate to good in vitro antitumor activities and were validated as p53-MDM2 inhibitors, which represented promising lead compounds for antitumor drug discovery.
Organic & Biomolecular Chemistry published new progress about Aldol condensation catalysts, stereoselective. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Related Products of 3893-18-3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary