Yanai, Hikaru; Egawa, Saki; Yamada, Kenta; Ono, Junpei; Aoki, Motohide; Matsumoto, Takashi; Taguchi, Takeo published the artcile< 1,1-Bis(triflyl)alkadienes: Easy-To-Handle Building Blocks for Strongly Acidic Carbon Acids>, Synthetic Route of 3893-18-3, the main research area is unsaturated aldehyde triflylmethane condensation; bistriflylalkadiene preparation Mukaiyama aldol; carbon acid preparation catalysis.
1,1-Bis(triflyl)alkadienes I (Ar = C6H5, 4-CH3C6H4, 4-CH3OC6H4, 3-EtOC6H4, 4-ClC6H4, 2-BrC6H4, etc.) were easily prepared by mixing bis(triflyl)methane and α,β-unsaturated aldehydes and then used as easy-to-handle building blocks for the preparation of strongly acidic carbon acids. The reaction of these alkadienes with either NaBH4 or organocerium reagents gave the desired carbon acids through a β-selective nucleophilic addition reaction. Similar reactions of a 1,1-bis(trifyl)alkadiene with sterically bulky iPrMgBr resulted in a δ-selective alkylation instead. The present β-alkylation is the realization of the synthesis of β-branched 1,1-bis(triflyl)alkanes with an acidic C-H moiety. Furthermore, when submitted to a Mukaiyama aldol reaction, β-branched carbon acids had a higher catalyst activity than that of the corresponding nonbranched carbon acids.
Asian Journal of Organic Chemistry published new progress about Acidity. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Synthetic Route of 3893-18-3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary