Adding a certain compound to certain chemical reactions, such as: 3972-64-3, name is 1-Bromo-3-(tert-butyl)benzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3972-64-3, Application In Synthesis of 1-Bromo-3-(tert-butyl)benzene
To a solution of 1 (15mg, 0.079mmol), 2 (33mg, 0.158mmol) and Cs2CO3 (128mg, 0.395mmol) in DMF (lmL) were added 2 mg of Pd(dba)2 and 2 mg of Xantphos. The suspension was degassed under vacuum and purged with N2 several times. The mixture was stirred at 120 ¡ãC for 6h. LCMS showed the SM was consumed completely. Then the reaction mixture was diluted with EA (10mL) and washed with brine (2mL) twice. The organic solution was dried over anhydrous Na2SO4, filtered, concentrated under reduced pressure and purified by p-TLC to give the desired compound Compound 221 (3mg, yield: 12percent). LCMS: m/z, 323.2 (M+H)+; 1HNMR (CDCl3, 400MHz): delta 8.62(d, J=4.8, 1H), 7.68~7.73(m, 1H), 7.52(d, J=7.6, 1H), 7.30(t, J=6.4, 1H), 7.20(t, J=8.0, 1H), 6.79(d, J=7.2, 1H), 6.58(s, 1H), 6.41(d, J=5.6, 1H), 3.92(s, 1H), 3.86(s, 1H), 3.56~3.60(m, 2H), 2.61~2.74(m, 1H), 2.47~2.56(m, 1H), 1.32(s,9H).
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Reference:
Patent; HUA MEDICINE (SHANGHAI) LTD.; CHEN, Li; BALDWIN, John J.; WU, Chengde; SHEN, Chunli; WO2014/124560; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary