Stoicescu-Crivetz, L.; Mandasescu, L. published the artcile< The antituberculotic action of some hydrazide and hydrazone derivatives of the p-amino-o-halobenzoic acids>, Category: bromides-buliding-blocks, the main research area is .
The following derivatives of the p-amino-o-halobenzoic acids were prepared to test the hydrazides and hydrazones for their tuberculostatic activity. The Me ester (I) of 2,4-Cl(O2N)C6H3CO2H (II) (6 g.), obtained by slowly adding 8 mL. concentrated H2SO4 to a solution of 6 g. II in 160 mL. MeOH and heating 6-8 h., m. 78-80° (from dilute EtOH). The analogous Br (III), m. 84°, and the iodo, m. 88°, compounds were prepared in the same way. 2,4-Cl(H2N)C6H3CO2Me, obtained by reduction of I with SnCl2 and HCl, m. 104° (from H2O). The Br, m. 94°, and iodo, m. 120°, analogs were obtained similarly. The hydrazide (1.5 g.) of 2,4-Cl(H2N)C6H3CO2H, prepared by adding dropwise 3 g. N2H4.H2O to 3 g. I, m. 175° (from dilute EtOH). The Br analog was obtained by the same method from III. 4-Amino-2-chlorobenzoylhydrazones of the following aldehydes were prepared: o-HOC6H4CHO, m. 190°; BzH, m. 195°; m-HOC6H4CHO, m. 226°; p-Me2NC6H4CHO; p-AcNHC6H4CHO, m. 255°. 4-Amino-2-bromobenzoylhydrazones: o-HOC6H4CHO, m. 215°; m-HOC6H4CHO, m. 226°; p-Me2NC6H4CHO, m. 207°. The hydrazides and hydrazones had a very weak antituberculotic action.
Studii si Cercetari de Chimie published new progress about Catalysts. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Category: bromides-buliding-blocks.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary