Erdogan, Merve; Kilic, Burcu; Sagkan, Rahsan Ilikci; Aksakal, Fatma; Ercetin, Tugba; Gulcan, Hayrettin O.; Dogruer, Deniz S. published their research in European Journal of Medicinal Chemistry in 2021. The article was titled 《Design, synthesis and biological evaluation of new benzoxazolone/benzothiazolone derivatives as multi-target agents against Alzheimer’s disease》.Recommanded Product: 14660-52-7 The article contains the following contents:
In this study, four series of compounds I [R = N(Me)(Bn), N(CH2)2CH(Ph)(CH2)2, N(CH2)2N(Bn)(CH2)2, etc.; X = O, S], II [n = 2,3] and III with benzoxazolone and benzothiazolone cores were designed, synthesized and evaluated as multifunctional agents against Alzheimer’s disease (AD). Addnl., in order to shed light on the effect of the carbonyl groups of benzoxazolone/benzothiazolone, benzoxazole/benzothiazole-containing analogs were also synthesized and evaluated. Inhibition potency of all final compounds towards cholinesterase enzymes and their antioxidant activity were tested. Subsequently, the anti-inflammatory activity, cytotoxicity, apoptosis, and Aβ aggregation inhibition tests were also performed for selected compounds The results indicated that compounds II [R = N(CH2)2CH(Ph)(CH2)2, X = S, n = 3] and III [R = N(CH2)2CH(Ph)(CH2)2, X = S] were considered as promising multi-functional agents for further investigation against AD. The reversibility, kinetic and mol. docking studies were also performed for the compounds with the highest AChE III [R = N(CH2)2CH(Ph)(CH2)2, X = S] and BChE II [R = N(CH2)2CH(Ph)(CH2)2, X = S, n = 3] inhibitory activities.Ethyl 5-bromovalerate(cas: 14660-52-7Recommanded Product: 14660-52-7) was used in this study.
Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Recommanded Product: 14660-52-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary