Application of 3814-30-0, These common heterocyclic compound, 3814-30-0, name is (Bromomethyl)cyclopentane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a solution of 6 (0.16 g, 0.85 mmol) in DMF (10 mL) was added K2CO3 (0.19 g, 1.40 mmol) and a solution of R1Br (1.0 mmol) in DMF (3 mL) was added dropwise. The reaction mixture was warmed to 70C and stirred for 6-12 h. After cooling to room temperature, the mixture was then poured in water (80 mL) and extracted with EtOAc (3 ¡Á 20 mL), and then washed with brine, dried with Na2SO4. The organic extracts were concentrated in vacuo and the residue was purified by flash chromatography (dichloromethane/methanol) to yield target compounds A1-A14 in yields ranging from 68.7% to 77.3%.
Statistics shows that (Bromomethyl)cyclopentane is playing an increasingly important role. we look forward to future research findings about 3814-30-0.
Reference:
Article; Wang, Yinhu; Mowla, Rumana; Guo, Liwei; Ogunniyi, Abiodun D.; Rahman, Taufiq; De Barros Lopes, Miguel A.; Ma, Shutao; Venter, Henrietta; Bioorganic and Medicinal Chemistry Letters; vol. 27; 4; (2017); p. 733 – 739;,
Bromide – Wikipedia,
bromide – Wiktionary