Recommanded Product: 2623-87-2In 2021 ,《Synthesis and Biological Activity of Novel Antifungal Leads: 3,5-Dichlorobenzyl Ester Derivatives》 was published in Journal of Agricultural and Food Chemistry. The article was written by Du, Shaoqing; Yuan, Qinglong; Hu, Xueping; Fu, Wen; Xu, Qi; Wei, Ziyi; Xu, Jiazheng; Shao, Xusheng; Qian, Xuhong. The article contains the following contents:
Succinate dehydrogenase (SDH) is one of the most important mol. targets for the development of new fungicides. Carboxamide fungicides are a class of SDH inhibitors widely used to inhibit highly destructive plant pathogens. Although cases of resistance have been found in fungal pathogens due to the unrestricted use in recent years, there is still demand for new compounds with improved fungicidal activity. Therefore, a series of ester compounds were designed to investigate potential novel antifungal mols. First, the antifungal activity of different benzyl alc. compounds (A1-A21) was tested, and a highly active fragment (3,5-dichlorobenzyl alc.) was found. Subsequently, various compounds were synthesized by esterification between different acids and 3,5-dichlorobenzyl alc., among which compound (I) exhibited remarkable antifungal activity against Botrytis cinerea and Rhizoctonia solani with EC50 values of 6.60 and 1.61 mg/L, resp., which were comparable to those of com. fungicide boscalid (EC50 = 1.24 and 1.01 mg/L). In vivo testing further demonstrated that compound I was effective in suppressing B. cinerea (200 mg/L, 50.9%). Moreover, SDH inhibition assays, fluorescence quenching anal., and determination of mitochondrial membrane potential revealed that compound I has similar effects to boscalid. Furthermore, the fungicidal activity of target compounds can be maintained by modifying the amide bond to an ester bond. These results will provide basis for the development of novel fungicides. In the experiment, the researchers used many compounds, for example, 4-Bromobutanoic acid(cas: 2623-87-2Recommanded Product: 2623-87-2)
4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Recommanded Product: 2623-87-2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary