《6,7-Benzotropolone Syntheses Based on Ring-Closing Metatheses and Four-Electron Oxidations》 was written by Kreibich, Michael; Gemander, Manuel; Peter, David; Yadav, Dharmendra B.; de Koning, Charles B.; Fernandes, Manuel A.; Green, Ivan R.; van Otterlo, Willem A. L.; Brueckner, Reinhard. Computed Properties of C9H11BrO3This research focused onvinylaryl ketone ring closing metathesis oxidation selenium Grubbs catalyst; benzotropolone preparation. The article conveys some information:
Four homoallyl ortho-vinylaryl ketones, e. g., I – 1,8-dienes of sorts – were prepared by several approaches. In the presence of 1-2 mol-% Grubbs-II catalyst, they ring-closed to give 6,7-dihydrobenzocyclohepten-5-ones, e.g., II, in 90-96% yield. With SeO2 the parent compound delivered benzocyclohepten-5-one (III) and/or selenium-containing compounds, e.g., IV, but no more than traces of 6,7-benzotropolone (V). However, V was accessible from compound II via the sodium enolate and allowing it to react with a stream of oxygen (43% yield). The sodium enolates of the substituted 6,7-dihydrobenzocyclohepten-5-ones and oxygen underwent analogous 4-electron oxidations This furnished the substituted 6,7-benzotropolones. In contrast, the corresponding lithium enolates were inert towards oxygen. The 6,7-dihydrobenzocyclohepten-5-one was also accessed differently, namely by a Grubbs-II catalyst-mediated RCM/C=C migration tandem reaction of the allyl ortho-allylaryl ketone VI – another 1,8-diene of sorts (90% yield). The experimental process involved the reaction of 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Computed Properties of C9H11BrO3)
1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Computed Properties of C9H11BrO31-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary