Electric Literature of 876-53-9,Some common heterocyclic compound, 876-53-9, name is 1,3-Dibromoadamantane, molecular formula is C10H14Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a 250 ml round bottom flask, 1,3-dibromoadamantane (15 mmol), cuprous oxide (40 mmol), and DMAC (20 ml) were refluxed for 48 hours under an argon atmosphere.The obtained intermediate was cooled to room temperature, added to water, then filtered through a pad of Celite, and the filtrate was extracted with dichloromethane.The organic phase was then washed with water and the organic phase was dried over anhydrous magnesium sulfate.After filtering and evaporating the organic phase, the crude product was purified by silica gel column chromatography.The intermediate product H14-1 was obtained.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,3-Dibromoadamantane, its application will become more common.
Reference:
Patent; Shanghai Tianma Organic Shine Display Co., Ltd.; Dai Wenpeng; Gao Wei; Niu Jinghua; Zhang Lei; Lu Yan; Deng Dongyang; (40 pag.)CN110156756; (2019); A;,
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