In 2022,Galster, Florian; Postges, Timo; Hanekamp, Walburga; Lehr, Matthias published an article in Archiv der Pharmazie (Weinheim, Germany). The title of the article was 《ω-(5-Phenyl-2H-tetrazol-2-yl)alkyl-substituted hydrazides and related compounds as inhibitors of amine oxidase copper containing 3 (AOC3)》.Synthetic Route of C5H9BrO2 The author mentioned the following in the article:
Recently, 6-(5-phenyl-2H-tetrazol-2-yl)hexan-1-amine was found to be a tight-binding substrate of AOC3. To obtain novel inhibitors of the enzyme, the amino group of this substrate was replaced with functional groups that occur in known AOC3 inhibitors, such as hydrazide or glycine amide moieties. In addition, derivatives of the compounds I [R = NHNH2, OEt, NH(CH2)2NH2, NH(CH2)3NH2, 3-(tert-butoxycarbonylamino)propylamino; n = 1, 2, 5, 6, etc.], II [R2 = HNC(O)CH2NH2, HNC(O)OPh, 2-(aminomethyl)imidazol-1-yl, etc.] obtained in this way were prepared The obtained hydrazide I [R = NHNH2; n = 6] which proved to be the most effective, was subjected to further structural modifications. Selected hydrazides I [R = NHNH2; n = 1, 6] were evaluated for selectivity toward some other amine oxidases. The results came from multiple reactions, including the reaction of Ethyl 3-bromopropanoate(cas: 539-74-2Synthetic Route of C5H9BrO2)
Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Synthetic Route of C5H9BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary