COA of Formula: C7H13BrO2In 2022 ,《Insight on pyrimido[5,4-g]indolizine and pyrimido[4,5-c]pyrrolo[1,2-a]azepine systems as promising photosensitizers on malignant cells》 appeared in European Journal of Medicinal Chemistry. The author of the article were Barreca, Marilia; Ingarra, Angela Maria; Raimondi, Maria Valeria; Spano, Virginia; De Franco, Michele; Menilli, Luca; Gandin, Valentina; Miolo, Giorgia; Barraja, Paola; Montalbano, Alessandra. The article conveys some information:
Searching for new small mols. as photosensitizing agents, the authors have developed a class of twenty-five pyrimido[5,4-g]indolizines I (R = H, COOEt, COOiPr, R1 = H, Ph, COMe, cyclohexyl, cyclopentyl, n = 1) and pyrimido[4,5-c]pyrrolo[1,2-a]azepines I (R = COOEt, COOiPr, R1 = H, Ph, cyclohexyl, cyclopentyl, n = 2) with a good substitution pattern defining a versatile synthetic pathway to approach the title ring systems. All compounds were evaluated for their photocytotoxicity on a triple neg. human breast cancer cell line (MDA-MB-231) in the dark and under UVA light (2.0 J/cm2). The most effective compounds exhibited a photoantiproliferative activity with IC50 values up to nanomolar ranges. Interestingly, these newly developed compounds showed high selectivity towards cancerous cells with respect to non-cancerous ones. Moreover, four representative derivatives were also phototoxic against an addnl. human HER2 pos. breast cancer cell line (HCC1954) and against the HER2 pos. vesical cancer cell line (T24) harboring Hras mutation. Mechanistic studies performed in triple neg. MDA-MB-231 cancer cells revealed the ability of the compounds to increase reactive oxygen species (ROS) production and to induce a thiol redox stress, thus triggering cancer cell death through apoptosis. Apoptotic cell death was also induced in highly aggressive and metastatic HER2 pos. Hras mutated T24-treated bladder cancer cells. Overall, data confirm that these new small photosensitizing agents may represent very promising candidates for phototherapy application against highly aggressive and resistant cancers. The results came from multiple reactions, including the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7COA of Formula: C7H13BrO2)
Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.COA of Formula: C7H13BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary