In 2016,Joshi, Shrinivas D.; Kumar, Devendra; Dixit, Sheshagiri R.; Tigadi, Nageshwar; More, Uttam A.; Lherbet, Christian; Aminabhavi, Tejraj M.; Yang, Kap Seung published 《Synthesis, characterization and antitubercular activities of novel pyrrolyl hydrazones and their Cu-complexes》.European Journal of Medicinal Chemistry published the findings.Electric Literature of C6H5Br2N The information in the text is summarized as follows:
Novel pyrrolyl hydrazones and their copper complexes were synthesized and characterized using anal. and spectral techniques to show the tetrahedral geometry for Cu(II) complexes. Biol. activities of hydrazones were assessed to understand the role of metal ion on their biol. activity and the effect of pyrrolyl hydrazones. In vitro antitubercular activity against Mycobacterium tuberculosis of the metal complexes exhibited the highest antitubercular activity that are quite close to rifampicin (0.4 μg/mL), giving a MIC of 0.8 μg/mL. All other compounds showed good activity with the MIC values ranging from 1.6 to 100 μg/mL. A comparative study of inhibition values of the ligands and their complexes showed higher antimicrobial activity of the complexes than the ligands. Some compounds have a good activity against InhA and in particular, compounds 12r, 13b and 13r exhibited > 60% binding with the enzyme even at 5 μM (exhibited good IC50 up to 2.4 μM). Most of the active mols. have a very less cytotoxicity against the human lung cancer cell-line A549. The docking and 3D-QSAR studies were carried out to provide some insights into the mechanism of action for this class of compounds3,5-Dibromoaniline(cas: 626-40-4Electric Literature of C6H5Br2N) was used in this study.
3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Electric Literature of C6H5Br2N
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary