In 2017,Yuan, William; Jiang, Dadi; Nambiar, Dhanya K.; Liew, Lydia P.; Hay, Michael P.; Bloomstein, Joshua; Lu, Peter; Turner, Brandon; Le, Quynh-Thu; Tibshirani, Robert; Khatri, Purvesh; Moloney, Mark G.; Koong, Albert C. published 《Chemical Space Mimicry for Drug Discovery》.Journal of Chemical Information and Modeling published the findings.Recommanded Product: 1129-28-8 The information in the text is summarized as follows:
The authors describe a new library generation method, Machine-based Identification of Mols. Inside Characterized Space (MIMICS) that generates sets of mols. inspired by a text-based input. MIMICS-generated libraries were found to preserve distributions of properties while simultaneously increasing structural diversity. Newly identified MIMICS-generated compounds were found to be bioactive as inhibitors of specific components of the unfolded protein response (UPR) and the VEGFR2 pathway in cell-based assays, thus confirming that applicability of this methodol. towards drug design applications. Wider application of MIMICS could facilitate the efficient utilization of chem. space. In the experiment, the researchers used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Recommanded Product: 1129-28-8)
Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products. Recommanded Product: 1129-28-8
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary