These common heterocyclic compound, 57951-72-1, name is 1-Bromo-2-cyclopropylethyne, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 57951-72-1
General procedure: The (E)-alpha-stannyl-alpha,beta-unsaturated ester 1 (1.0 mmol) and the alkynylbromide 2 (1.1 mmol) were dissolved in DMF (8 mL) under Ar at room temperature. Pd(PPh3)4 (0.05 mmol) and CuI (0.75 mmol) were then added. The mixture was stirred for 20-24 h at room temperature and monitored by TLC (SiO2) for the disappearance of the starting (E)-alpha-stannyl-alpha,beta-unsaturated ester 1. The reaction mixture was diluted with diethyl ether (30 mL), filtered and then treated with 20% aqueous KF(10 mL) for 30 min before being dried over MgSO4 and concentrated at 40 C under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: light petroleum ether (30-60 C)/EtOAc, 19:1).
The synthetic route of 1-Bromo-2-cyclopropylethyne has been constantly updated, and we look forward to future research findings.
Reference:
Article; Wang, Pingping; Huang, Bin; Xie, Shiyun; Tuo, Yuxin; Cai, Mingzhong; Journal of Chemical Research; vol. 39; 11; (2015); p. 627 – 630;,
Bromide – Wikipedia,
bromide – Wiktionary