In 2019,Organic Chemistry Frontiers included an article by Koffi Teki, Dindet Steve-Evanes; Bil, Abed; Moreau, Vincent; Chagnault, Vincent; Fante, Bamba; Adjou, Ane; Kovensky, Jose. COA of Formula: C13H17BrO9. The article was titled 《Synthesis of multivalent S-glycoside analogs of a heparan sulfate sequence》. The information in the text is summarized as follows:
Glycosaminoglycans (GAGs) are involved in the regulation of a large number of biol. processes such as inflammation, cell signaling, angiogenesis, viral infection and coagulation. Unlike mols. isolated from tissues, pure mols., derived from organic synthesis, can prevent side effects and are very useful tools for understanding the structure-activity relationships of many biol. and pharmacol. activities. In our research group, we focus particularly on the synthesis of multivalent thioglycoside analogs. In this article, we report on the synthesis of new glycoclusters with thiodisaccharide units, S-analogs of heparan sulfate. The thiodisaccharide analog was obtained by nucleophilic displacement of a 4-triflate galactoside derivative, by an anomeric thiol of a glucuronic acid precursor. After modifying the aglycon part to introduce an azide, the thiodisaccharide was coupled to maltotriose scaffolds carrying one, two or three propargyl groups by CuAAC. After reading the article, we found that the author used (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3COA of Formula: C13H17BrO9)
(2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3) may be used for the synthesis of HMR1098-S-Glucuronide Methyl Ester, a new K-ATP-blocking agent being developed as a drug for prevention of sudden cardiac death.COA of Formula: C13H17BrO9
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary