In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 393-37-3, name is 5-Bromo-2-fluorobenzotrifluoride belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 5-Bromo-2-fluorobenzotrifluoride
A mixture of l-bromo-4-fluoro-3-(trifluoromethyl)benzene (5.02 g) and potassiumcyanide (1.38 g) in DMSO (20 ml) was heated at 80 C for 14 h. Water was added and themixture was extracted ether, the organic extracts were dried (MgSO4) and evaporated to givea brown oil. This was dissolved in DMSO (10 ml) and 4 M NaOH (10 ml) and heated at 100C for 16 h. 2 M Hcl (20 ml) was added and the mixture was extracted with DCM (threetimes), the organic extracts were dried (MgSO4), evaporated and purified by chromatography(silica, CH^Ck-MeOH-AcOH as eluent) to give the sub-title compound (1.99 g).MS: ESI (-ve): 268 [M-H]’ 100%.
The synthetic route of 393-37-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/21759; (2006); A1;,
Bromide – Wikipedia,
bromide – Wiktionary