Dankwardt, Sharon M.; Ferla, Steven; Krstenansky, John L.; Bhakta, Sunil; Ostrelich, Helene; Jarnagin, Kurt published an article in Bioorganic & Medicinal Chemistry Letters. The title of the article was 《Nonpeptide bradykinin antagonist analogs based on a model of a Sterling-Winthrop nonpeptide bradykinin antagonist overlapped with cyclic hexapeptide bradykinin antagonist peptide》.Reference of Methyl 5-(bromomethyl)-2-nitrobenzoate The author mentioned the following in the article:
A proposed overlap between cyclic hexapeptide bradykinin antagonist and nonpeptide bradykinin antagonists D- and L-3-(2-naphthyl)alanines I [R1 = Bu3P+, Bu3N+, H2N, HO, H2NC(:NH)NH, EtNHC(:NEt)NH, H-L-Arg-NH, H-D-Arg-NH, aca-D-Arg-NH; aca = 1-adamantylcarbonyl; R2 = H, CO2H; R3 = H, CH2CH2CO2H; X = cyclohexylimino, O] is discussed. Synthetic procedures for both enantiomers of I are given. Structural variations on both the peptides and nonpeptides support the proposed overlap based on an increase or decrease in the biol. activities of the antagonists. The experimental process involved the reaction of Methyl 5-(bromomethyl)-2-nitrobenzoate(cas: 88071-91-4Reference of Methyl 5-(bromomethyl)-2-nitrobenzoate)
Methyl 5-(bromomethyl)-2-nitrobenzoate(cas: 88071-91-4) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool. Reference of Methyl 5-(bromomethyl)-2-nitrobenzoate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary