Reference of 10269-01-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 10269-01-9 as follows.
General procedure: Various amines (2.00mmol) were dissolved in absolute alcohol (15mL) and then potassium carbonate (2.00mmol) was added. The mixture was stirred for 45min at room temperature. Compound 4 (1.00mmol) and potassium iodide (0.25mmol) were added and the mixture stirred and refluxed overnight. Then the mixture was poured into water (50mL), extracted with ethyl acetate to give the crude product. The crude product was purified by column chromatography using petroleum ether and ethyl acetate. 6-Chloro-2-methoxy-N-(3-bromobenzyl)acridin-9-amine (LXL-4): Yield 69%; mp 156-159 C; 1H NMR (400 MHz, CDCl3): delta 8.08 (d, 1H, J = 1.8 Hz), 7.99 (d, 1H, J = 9.4 Hz), 7.91 (d, 1H, J = 9.3 Hz), 7.61 (s, 1H), 7.45 (d, 1H, J = 7.8 Hz), 7.39 (dd, 1H, J = 9.4, 2.6 Hz), 7.28 (dd, 2H, J = 6.6, 2.7 Hz), 7.22 (t, 1H, J = 7.7 Hz), 7.09 (d, 1H, J = 2.5 Hz), 4.76 (s, 2H), 3.76 (s, 3H); 13C NMR (101 MHz, CDCl3): delta 156.43, 149.09, 148.15, 146.93, 141.72, 134.92, 131.49, 130.99, 130.55, 130.38, 128.33, 125.88, 125.25, 124.99, 123.62, 123.13, 118.57, 116.52, 99.04, 55.39, 53.87; HR-MS(ESI): calcd. for C21H16BrClN2O [M+H]+ 427.0213; found: 427.0224.
According to the analysis of related databases, 10269-01-9, the application of this compound in the production field has become more and more popular.
Reference:
Article; Lang, Xu-Liang; Sun, Qin-Sheng; Chen, Yu-Zong; Li, Lu-Lu; Tan, Chun-Yan; Liu, Hong-Xia; Gao, Chun-Mei; Jiang, Yu-Yang; Chinese Chemical Letters; vol. 24; 8; (2013); p. 677 – 680;,
Bromide – Wikipedia,
bromide – Wiktionary