Yanagi, Kouichi; Komatsu, Toru; Ogihara, Shusuke; Okabe, Takayoshi; Kojima, Hirotatsu; Nagano, Tetsuo; Ueno, Tasuku; Hanaoka, Kenjiro; Urano, Yasuteru published the artcile< Establishment of live-cell-based coupled assay system for identification of compounds to modulate metabolic activities of cells>, Synthetic Route of 16426-64-5, the main research area is fluorescence imaging metabolic activity tumor cell glycolysis; chemical biology; coupled assays; fluorescent probes; glucolysis; glutaminolysis; metabolism.
In this study, we present a live-cell-based fluorometric coupled assay system to identify the compounds that can regulate the targeted metabolic pathways in live cells. The assay is established through targeting specific metabolic pathways and using “” input “” and “”output “” metabolite pairs. The changes in the extracellular output that are generated and released into the extracellular media from the input are assessed as the activity of the pathway. The screening for the glycolytic pathway and amino acid metabolism reveals the activities of the present drugs, 6-BIO and regorafenib, that regulate the metabolic fate of tumor cells.
Cell Reports published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Synthetic Route of 16426-64-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary