Liu, Shunjie; Ou, Hanlin; Li, Yuanyuan; Zhang, Haoke; Liu, Junkai; Lu, Xuefeng; Kwok, Ryan T. K.; Lam, Jacky W. Y.; Ding, Dan; Tang, Ben Zhong published the artcile< Planar and Twisted Molecular Structure Leads to the High Brightness of Semiconducting Polymer Nanoparticles for NIR-IIa Fluorescence Imaging>, Application In Synthesis of 184239-35-8, the main research area is mol structure brightness semiconducting polymer nanoparticle NIR fluorescence imaging.
Semiconducting polymer nanoparticles (SPNs) emitting in the second near-IR window (NIR-II, 1000-1700 nm) are promising materials for deep-tissue optical imaging in mammals, but the brightness is far from satisfactory. Herein, the authors developed a mol. design strategy to boost the brightness of NIR-II SPNs: structure planarization and twisting. By integration of the strong absorption coefficient inherited from planar π-conjugated units and high solid-state quantum yield (ΦPL) from twisted motifs into one polymer, a rise in brightness was obtained. The resulting pNIR-4 with both twisted and planar structure displayed improved ΦPL and absorption when compared to the planar polymer pNIR-1 and the twisted polymer pNIR-2. Given the emission tail extending into the NIR-IIa region (1300-1400 nm) of the pNIR-4 nanoparticles, NIR-IIa fluorescence imaging of blood vessels with enhanced clarity was observed Moreover, a pH-responsive poly(β-amino ester) made pNIR-4 specifically accumulate at tumor sites, allowing NIR-IIa fluorescence image-guided cancer precision resection. This study provides a mol. design strategy for developing highly bright fluorophores.
Journal of the American Chemical Society published new progress about Blood vessel. 184239-35-8 belongs to class bromides-buliding-blocks, and the molecular formula is C26H18Br2, Application In Synthesis of 184239-35-8.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary