Mu, Xingye; Yu, Hanxiao; Peng, Henian; Xiong, Wenrui; Wu, Ting; Tang, Wenjun published the artcile< Construction of Various Bridged Polycyclic Skeletons by Palladium-Catalyzed Dearomatization>, Recommanded Product: 4-Bromo-3-formylbenzonitrile, the main research area is tetracyclic arene chemoselective enantioselective preparation; aspernomine strychnochromine core ring system preparation; dracaenone analog preparation; palladium benzoxaphospholane catalyst dearomatization cyclization bromoaryl bicycle; enantioselective desymmetrization bromophenyl bromobenzyl bicycle palladium benzoxaphospholane catalyst; bridged tetracyclic systems; dearomative cyclization; homogeneous catalysis; monophosphorus ligands; palladium.
In the presence of [Pd(cinnamyl)Cl]2, an arylbenzoxaphospholane ligand, and K2CO3 in toluene, bromoaryl-substituted bicyclic phenols such as I underwent dearomative cyclization reactions to yield tetracyclic arenes such as II; a variety of ring systems with differing bridging patterns and carbocyclic and heterocyclic linkers were prepared using the method. The method was used to prepare partial ring systems for the alkaloids aspernomine and strychnochromine and to prepare dracaenone analogs. Bis(bromophenyl)- and bis(bromobenzyl)-substituted bicycles underwent enantioselective desymmetrization by dearomative cyclization using [Pd(cinnamyl)Cl]2 and nonracemic arylbenzoxaphospholane ligands to give bromoaryl- and bromobenzyl-substituted tetracycles in 33-99% ee (absolute configuration undetermined).
Angewandte Chemie, International Edition published new progress about Aryl bromides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 89003-95-2 belongs to class bromides-buliding-blocks, and the molecular formula is C8H4BrNO, Recommanded Product: 4-Bromo-3-formylbenzonitrile.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary