In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 129316-09-2 as follows. category: bromides-buliding-blocks
Step 1 : Ethyl 5-(3-bromo-5-(teff-butyl)phenyl)-1-(cvclohexylmethyl)-2-iTiethyl-1 -/-pyrrole-3- carboxylate (12a) To a solution of compound P18a (643 mg, 1.71 mmol ) in 1 ,4-dioxane/H20 (3 mlJ0.8 ml_) 1 ,3-dibromo-5-(tert-butyl)benzene (595 mg, 2.05 mmol), Cs2C03 (1.11 g, 3.42 mmol) and Pd(PPh3)4 (66 mg, 0.17 mmol) were added under N2. The mixture was stirred under microwave at about 110C for 2.5 h. Removal of the solvents and purification by prep. TLC (PE/EA = 20/1) yielded compound 12a (275 mg, 35%) as yellow solid.
According to the analysis of related databases, 129316-09-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PHENEX PHARMACEUTICALS AG; STEENECK, Christoph; KINZEL, Olaf; GEGE, Christian; KLEYMANN, Gerald; HOFFMANN, Thomas; WO2013/79223; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary