The author of 《Synthesis of vinca alkaloid-triphenylphosphine derivatives having potential antitumor effect》 were Keglevich, Andras; Szigetvari, Aron; Dekany, Miklos; Szantay, Csaba Jr.; Keglevich, Peter; Hazai, Laszlo. And the article was published in Phosphorus, Sulfur and Silicon and the Related Elements in 2019. Safety of 4-Bromobutanoic acid The author mentioned the following in the article:
The successful therapy of cancer is still unresolved. For that reason enormous efforts are being made to increase the effectiveness of anticancer drugs and reduce their side effects at least. An important approach to the development of selective mols. is the synthesis of drug conjugates, also called as “”hybrids””. Taking this into consideration two Vinca alkaloid derivatives conjugated with triphenylphosphine have been synthesized. The incorporation of the mentioned two pharmacophores in the same mol. could amplify the evolving cumulative antineoplastic impact and/or counterbalance the side effects. Thus a development of hybrid anticancer mols. has been started by synthesis of Vinca alkaloid-triphenylphosphine conjugates, which could have higher efficacies and safety profiles than the present drugs available in market. The experimental part of the paper was very detailed, including the reaction process of 4-Bromobutanoic acid(cas: 2623-87-2Safety of 4-Bromobutanoic acid)
4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Safety of 4-Bromobutanoic acid
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary