HPLC of Formula: 17696-11-6In 2021 ,《Rose bengal conjugated gadolinium complex as a new multimodal imaging agent targeting presynaptic vesicular glutamate transporters》 was published in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands). The article was written by Kim, Soyeon; Kim, Hee-Kyung; Baek, Ah Rum; Sung, Bokyung; Yang, Byeong Woo; Kim, Yeoun-Hee; Lee, Jung-jin; Yang, Ji-ung; Shin, Chang-Hoon; Jung, Hoesu; Kim, Minsup; Cho, Art E.; Lee, Taekwan; Chang, Yongmin. The article contains the following contents:
Glutamate is an important excitatory neurotransmitter, and vesicular glutamate transporters (VGLUTs) are critical in regulating the extent of glutamate release. Because initial increase and late stage decrease in VGLUT expression were implicated in progressive Alzheimer′s disease (AD), VGLUTs can be a new imaging target for diagnosing AD. In this study, we have designed and synthesized a new multimodal gadolinium contrast agent conjugated with rose bengal to target VGLUTs (Gd-DO3A-RB). In addition to high kinetic and pH stability, magnetic resonance and fluorescence imaging using Gd-DO3A-RB showed high affinity to VGLUT1. Using the AD animal model (5XFAD), in vivo MRI with a Gd-DO3A-RB showed less MR signal enhancement in 5XFAD mouse brain than that of age-matched normal C57BL/6 mouse, suggesting a late stage decrease in VGLUT expression in AD animal model. Therefore, this new VGLUT targeting gadolinium contrast agent demonstrated a strong potential as a new diagnostic tool for AD with multimodal imaging capability. After reading the article, we found that the author used 8-Bromooctanoic acid(cas: 17696-11-6HPLC of Formula: 17696-11-6)
8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.HPLC of Formula: 17696-11-6
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary