Adding a certain compound to certain chemical reactions, such as: 17247-58-4, name is (Bromomethyl)cyclobutane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17247-58-4, SDS of cas: 17247-58-4
To a solution of diacetyl-2-acetamido malonate (39, 2.0 g,9.2 mmol) in DMSO was added Cs2CO3 (4.5 g, 13.8 mmol) under an N2 atmosphere. Bromomethylcyclobutane (1.6 g, 10.5 mmol) wasadded to the reaction. The reaction mixturewas heated to 60 C and maintained for 12 h until the completion of reaction as monitored by TLC. The reaction mixture was cooled to rt, poured into ice-coldH2O (100 mL) and extracted with EtOAc (100 mL 3). The organiclayer was washed with brine and dried over Na2SO4. The solid wasfiltered off, and the filtrate was concentrated under reduced pressure to give 2.0 g of 40h (76% yield).
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Reference:
Article; Xue, Xiaoqian; Zhang, Yan; Wang, Chao; Zhang, Maofeng; Xiang, Qiuping; Wang, Junjian; Wang, Anhui; Li, Chenchang; Zhang, Cheng; Zou, Lingjiao; Wang, Rui; Wu, Shuang; Lu, Yongzhi; Chen, Hongwu; Ding, Ke; Li, Guohui; Xu, Yong; European Journal of Medicinal Chemistry; vol. 152; (2018); p. 542 – 559;,
Bromide – Wikipedia,
bromide – Wiktionary