Singh, Sudhir K.; Ruchelman, Alexander L.; Li, Tsai-Kun; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J. published the artcile< Nitro and Amino Substitution in the D-Ring of 5-(2-Dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: Effect on Topoisomerase-I Targeting Activity and Cytotoxicity>, Application of C7H4BrNO4, the main research area is methylenedioxydibenzonaphthyridinone preparation topoisomerase inhibiting activity cytotoxicity; structure methylenedioxydibenzonaphthyridinone topoisomerase inhibiting activity cytotoxicity; nitro amino substitution methylenedioxydibenzonaphthyridinone topoisomerase targeting activity cytotoxicity.
Methylenedioxydibenzo[c,h][1,6]naphthyridinones I (R, R1, R2 = H, H2N, O2N; R3 = Me2N, Et) are prepared as potential inhibitors of human topoisomerase I. Coupling of 2-bromobenzoic acids to amino(methylenedioxy)quinolines [prepared by displacement of 4-chloro-6,7-(methylenedioxy)quinoline] followed by palladium-catalyzed intramol. Heck arylation reactions and reduction of the pendant nitro groups (if present) yields methylenedioxydibenzonaphthyridinones I (R, R1, R2 = H, H2N, O2N; R3 = Me2N, Et). I (R = H; R1 = H, O2N; R2 = O2N, H; R3 = Me2N) inhibit topoisomerase I-mediated DNA cleavage more effectively and are more cytotoxic than camptothecin; I have topoisomerase I inhibiting activities comparable to dimethoxydibenzonaphthyridinone I (R = H; R1 = R2 = MeO; R3 = Me2N).
Journal of Medicinal Chemistry published new progress about Cytotoxic agents. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Application of C7H4BrNO4.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary