Reference of 10016-52-1, The chemical industry reduces the impact on the environment during synthesis 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, I believe this compound will play a more active role in future production and life.
In a 25 ml four-necked flask, 0.52 g (2.0 mmol) of 4-phenylaminodibenzofuran, 0.33 g (1.0 mmol) of 2,8-dibromodibenzofuran, 500 mg (5.2 mmol) of sodium t-butoxide, 10 ml of dehydrated toluene In addition, nitrogen bubbling was performed for 1 hour. after that,Pd2 (dba) 392 mg (0.10 mmol),After adding 58 mg (0.20 mmol) of tri-t-butylphosphonium tetrafluoroborate, the mixture was heated under reflux for 12 hours while stirring under a nitrogen stream. The formation of the desired product was confirmed by TLC and MS. The reaction solution was cooled to room temperature, and the organic layer was extracted with toluene, washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated to obtain a brown viscous product. The resulting gum was dissolved in 5 ml of toluene and loaded onto the column. The crude product was directly purified by silica gel column chromatography (developing solvent: toluene / hexane = 1/4) to obtain 0.51 g of the target product HTM5 in a yield of 75%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,8-Dibromodibenzo[b,d]furan, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; National University Corporation Yamagata University; Sasabe, Hisahiro; Kido, Junji; Kamata, Takahiro; (21 pag.)JP2019/26556; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary