Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10269-01-9, name is (3-Bromophenyl)methanamine, A new synthetic method of this compound is introduced below., SDS of cas: 10269-01-9
N-(3-Bromobenzyl)-2-(4-fluoro-N-isopropylphenylsulfonamido)acetamide. A 250-mL single- neck round-bottomed flask equipped with a magnetic stirrer was charged with 2-(4-fluoro-N- isopropylphenylsulfonamido)acetic acid (1.0 g, 3.64 mmol), (3-bromophenyl)methanamine (690 mg, 3.64 mmol), HATU (2.76 g, 7.28 mmol), TEA (3 ml), and CH2C12 (50 mL). The mixture was stuffed at room temperature for 2 h and added 2% KHSO4 solution. The resulting mixture was extracted with DCM. The combined organic layer was concentrated under reduced pressure. The residue was purified by silica-gel column chromatography eluting with 3:1 PE/EA to afford the title compound as white solid (960 mg, 60%). MS-ESI: [M+H] 443.1.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BROTHERTON-PLEISS, Christine E.; CHEN, Huifen; CHEN, Shaoqing; CHEN, Zhi; ERICKSON, Shawn David; ESTRADA, Anthony; KIM, Kyungjin; LI, Hongju; LOVEY, Allen John; LYSSIKATOS, Joseph P.; QIAN, Yimin; SO, Sung-Sau; WOVKULICH, Peter Michael; YI, Lin; WO2014/49047; (2014); A1;,
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