Adding a certain compound to certain chemical reactions, such as: 2924-09-6, name is 5-Bromo-2-fluoroaniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2924-09-6, SDS of cas: 2924-09-6
A solution of 5-bromo-2-fluoroaniline (10 g, 52 mmol) in toluene (150 ml) was treated with 4-bromobutyryl chloride (6.1 ml, 52 mmol) and then heated at [100C] for 14 h. The reaction was cooled then washed with water, 10% sodium carbonate, IN HCl and water, dried over anhydrous magnesium sulphate, filtered and concentrated im vacuo. The resulting tan solid was triturated with 5% ether in isohexane and collected by filtration to afford [4-BROMO-N- (5-BROMO-2-FLUOROPHENYL)] butyramide. This solid was dissolved in anhydrous [NN-DIMETHYLFORMAMIDE] (150 ml) then treated with sodium hydride (1.4 g of a 60% dispersion in oil) added in portions over 5 min. The resulting mixture was stirred at [60C] for 60 min, cooled and treated with methanol (10 ml). The reaction was diluted with water (1500 ml) and extracted with ether (2 x 400 ml). The organics were combined, washed with water (x 3), brine, dried over anhydrous magnesium sulphate, filtered and pre-adsorbed onto silica. Chromatography on silica gel, eluting with isohexane on a gradient of ethyl acetate (20-50%), gave [1- (5-BROMO-2-FLUOROPHENYL)] pyrrolidin-2-one (9.1 g, [67%)] as a straw-coloured solid: [8H] (400 MHz, CDCl3) 2.17-2. 25 (2H, m), 2. [55-2.] 59 (2H, m), 3. [80-3.] 84 (2H, m), 7.20 [(1H,] dd, J 10.5 and 9), 7.33- 7.37 [(1H,] m), 7.59 [(1H,] dd, J 7 and 2.5). 2-(8-Fluoroimidazo[1,2-a]pyridin-7-yl) propan-2-ol was coupled to [1-] (5-bromo-2-fluorophenyl) pyrrolidin-2-one as described in Example 6 to give [L- {2-NUORO-5- [8-FLUORO-7- (L-HYDROXY-L-METHYLETHYL)] imidazo [1, 2-a] pyridin-3- yl] phenyl} pyrrolidin-2-one as a pale yellow solid (114 mg, 31%): m/z [(ES+)] 372 [WHY]
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-2-fluoroaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME LIMITED; WO2003/99816; (2003); A1;,
Bromide – Wikipedia,
bromide – Wiktionary