Zhan, Yizhou; Liu, Tao; Ren, Jun; Wang, Zhongwen published the artcile< Lewis Acid-Catalyzed Intramolecular [3+2] Cross-Cycloaddition of Aziridine 2,2-Diesters with Conjugated Dienes for Construction of Aza-[n.2.1] Skeletons>, Quality Control of 89003-95-2, the main research area is Lewis acid intramol cross cycloaddition aziridine diester conjugate diene; aza skeleton preparation; aziridine; bridged ring; cycloaddition; medium-sized ring; regioselectivity.
A novel Lewis acid-catalyzed [3+2] intramol. cross-cycloaddition (IMCC) between aziridine 2,2-diesters and conjugated dienes has been developed. This is the first regiospecific IMCC of intramol. 1,3-dipolar cycloadditions of azomethine ylides with carbon=carbon double bonds, and supplies a general and efficient strategy for construction of structurally complex and diverse aza-[n.2.1] skeletons, e.g. I. The [3+2]IMCC could be carried out under mild conditions and in gram scale. More importantly, 3-alkyl-substituted aziridines were also successful. The excellent structural diversity, the facile operation and the versatile post-modifications will support the applications of the [3+2]IMCC in natural products synthesis and drugs discovery.
Chemistry – A European Journal published new progress about Aziridines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 89003-95-2 belongs to class bromides-buliding-blocks, and the molecular formula is C8H4BrNO, Quality Control of 89003-95-2.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary