Kandula, Venkata Ramana; Pothireddy, Mohanreddy; Babu, K. Suresh; Kapavarapu, Ravikumar; Dandela, Rambabu; Pal, Manojit published the artcile< Sonochemical synthesis of polyarylated oxazoles as potential cytotoxic agents>, Computed Properties of 3959-07-7, the main research area is polyarylated oxazole preparation ultrasound antitumor human.
The ultrasound assisted facile, rapid and one-pot synthesis of 2-aryl substituted 4,5-diphenyloxazoles I (Ar = C6H5, 4-FC6H4, 3-MeC6H4, etc.,) was achieved via the reaction of com. available benzoin (or 2-hydroxy-2-phenylacetophenone) with benzylamines in the presence of IBX under mild conditions. The methodol. involved initial IBX mediated conversion of benzoin to benzil and then reaction with benzylamine followed by intramol. cyclization (C-O bond formation) and finally aromatization in the presence of air in the same pot. The methodol. afforded a variety of desired products that were assessed for their cytotoxic properties against a number of cancerous and a non-cancerous cell lines. Compounds I (Ar = 4-MeOC6H4), I (Ar = 4-CF3OC6H4) and I (Ar = 3,4-CH3OC6H3) showed promising growth inhibition of these cell lines except the non-cancerous one and interactions with SIRT1 in silico as well as in vitro.
Tetrahedron Letters published new progress about Antitumor agents. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Computed Properties of 3959-07-7.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary