In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7499-66-3, name is 6-Bromonaphthalen-2-amine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 6-Bromonaphthalen-2-amine
Example 15 Synthesis of 2-bromo-6-(N-methylamino)Naphthalene (Intermediate 27) A solution of 2-amino-6-bromonaphthalene (2.0 g) in 1,4-dioxane (30 ml) was added dropwise with dimethyl sulfate (1300 mul) and stirred at room temperature for 46 hours.The reaction mixture was added with ethyl acetate (90 ml) and then added with 1 N aqueous sodium hydroxide (5 ml).This mixture was extracted with ethyl acetate (150 ml*3).The organic layer was washed with saturated brine and dried, and then the solvent was evaporated under reduced pressure.The residue was purified by flash column chromatography (hexane:ethyl acetate=15:1) to obtain the title compound (Intermediate 27, 152 mg).
The synthetic route of 7499-66-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shoda, Motoshi; Kuriyama, Hiroshi; US2004/44258; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary