Zhu, Jun; Zhang, Rui; Dong, Guangbin published the artcile< Orthogonal cross-coupling through intermolecular metathesis of unstrained C(aryl)-C(aryl) single bonds>, Electric Literature of 1530-33-2, the main research area is biaryl ruthenium catalyst regioselective orthogonal cross coupling reaction.
Ruthenium-catalyzed reversible C-C single-bond metathesis reaction that allowed redox- and pH-neutral biaryl synthesis. Assisted by directing groups, unstrained homo-biaryl compounds underwent aryl exchanges to generate cross-biaryl products, catalyzed by a well-defined air-stable ruthenium(II) complex. Functional groups reactive under typical cross-coupling reactions, such as halogen, silyl and boronate moieties, were compatible under the metathesis conditions. Mechanistic studies disclosed an intriguing ‘olefin-metathesis-like’ pathway that involved an unexpected heptacoordinated, 18-electron closed-shell intermediate. The distinct reaction mode discovered here is expected to inspire the development of more general C-C single-bond metathesis and orthogonal cross-coupling reactions.
Nature Chemistry published new progress about Biaryls Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1530-33-2 belongs to class bromides-buliding-blocks, and the molecular formula is C21H22BrP, Electric Literature of 1530-33-2.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary