Hassaballah, Aya I.; Ramadan, Sayed K.; Rizk, Sameh A.; El-Helw, Eman A. E.; Abdelwahab, Salwa S. published the artcile< Ultrasonic Promoted Regioselective Reactions of the Novel Spiro 3,1-Benzoxazon-Isobenzofuranone Dye Toward Some Organic Base Reagents>, Synthetic Route of 82-73-5, the main research area is spiro benzoxazinone isobenzofuranone nucleophile electrophile multicomponent reaction regioselective ultrasonic; antitumor antibacterial antifungal activity human green chem.
4′-Bromo-3′H-spiro[benzo[d][1,3]-oxazine-2,1′-isobenzofuran]-3′,4(1H)-dione dye is prepared via condensation of 2-aminobenzoic acid with 4-bromoisobenzofuran-1,3-dione under Ultrasonic, solvent-free and basic reaction conditions. The spiro product exhibited both electrophilic and nucleophilic centers. A series of nitrogen nucleophiles such as hydrazine, glycine, 2-aminopyridine, pyridin-2-ylmethanamine, 4-methoxyaniline, 4-aminoacetophenone, morpholine, piperidine or 1-ethylpiperazine and carbon electrophiles such as (chloromethyl)oxirane, Et chloroacetate, chloroacetyl chloride can be treated with 2-benzoxazine-2-yl benzoic acid (BBA) via multicomponent reaction. The fluorescence of the spiro product dyes decreases proportionally to the initial chloride concentration in the solution The chem. structures of the synthesized compounds can be confirmed by microanal., spectral data and optimized by quantum chem. parameters. Biol. evaluation showed that these synthesized spiro compounds exhibited moderate to good cytotoxic activity. Among them, compounds and displayed the best cytotoxic activity against MCF7 and Wl-38 cell lines.
Polycyclic Aromatic Compounds published new progress about Antibacterial agents. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Synthetic Route of 82-73-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary