Alkhaibari, Ibrahim S.; Kc, Hansa Raj; Roy, Subrata; Abu-gazleh, Mohd. K.; Gilmore, David F.; Alam, Mohammad A. published the artcile< Synthesis of 3,5-Bis(trifluoromethyl)phenyl-Substituted Pyrazole Derivatives as Potent Growth Inhibitors of Drug-Resistant Bacteria>, Recommanded Product: 4-Bromo-3-chloro-2-fluoroaniline, the main research area is trifluoromethyl phenyl pyrazole preparation antibacterial activity cytotoxicity SAR; Enterococcus faecalis; Enterococcus faecium; MRSA; Staphylococcus aureus; VRE; aniline; pyrazole.
The design, synthesis, and antimicrobial studies of 30 novel pyrazole derivatives I (R = C6H5, 3-FC6H4, 3,4-(F2)C6H3, etc.) have been described. Most of the synthesized compounds I are potent growth inhibitors of planktonic Gram-pos. bacteria with min. inhibitory concertation (MIC) values as low as 0.25μg/mL. Further studies led to the discovery of several lead compounds, which are bactericidal and potent against MRSA persisters. Compounds I (R = 4-BrC6H4, 3,5-(Cl)2-4-FC6H2, 4-Br-3-Cl-2-FC6H2) are potent against S. aureus biofilms with min. biofilm eradication concentration (MBEC) values as low as 1μg/mL.
Molecules published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 115843-99-7 belongs to class bromides-buliding-blocks, and the molecular formula is C6H4BrClFN, Recommanded Product: 4-Bromo-3-chloro-2-fluoroaniline.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary