Xia, Mengxin; Moussa, Ziad; Judeh, Zaher M. A. published the artcile< Acetic Acid-Catalyzed Selective Synthesis of N-Substituted 2-Amino-3-Cyanopyrroles via a Three-Component Reaction Between Carbohydrates, Primary Amines and Malononitrile>, Product Details of C7H8BrN, the main research area is carbohydrate amine malononitrile acetic acid catalyst cascade cyclization; acetoxyaminocyanopyrrole preparation.
Direct conversion of unprotected carbohydrates to N-heterocycles was challenging and highly desirable. A simple three-component synthesis of N-substituted 2-amino-3-cyanopyrrole key framework was developed from the reaction between unprotected carbohydrates, malononitrile and primary amines. The reaction proceeded under mild reaction conditions (AcOH catalyst, EtOH, 60 °C, 2 h), tolerated a wide substrate scope, worked smoothly on a 4 g scale and gave the pyrroles in up to 86% yield. The pyrroles were also converted into functional intermediates to demonstrated their versatility. NMR and LC-MS experiments supported a proposed cascade reaction mechanism. The approach demonstrated a robust upcycling process for the challenging synthesis of highly functionalized N-heterocyclic compounds from unprotected carbohydrates.
Asian Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Product Details of C7H8BrN.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary