Jiang, Zhiwei; Toffano, Martial; Vo-Thanh, Giang; Bournaud, Chloee published the artcile< Bifunctional N-Heterocyclic Carbene-Catalyzed Highly Enantioselective Trans-Cyclopentannulation of Enals and Enones via Homoenolate>, Computed Properties of 3893-18-3, the main research area is cyclopentene preparation enantioselective diastereoselective; enal enone trans cyclopentannulation bifunctional heterocyclic carbene catalyst.
An efficient and flexible synthesis of a new class of chiral bifunctional NHC catalysts I [R = i-Pr, i-Bu, Bn, cyclohexyl; Ar = Ph, 3,5-bis(trifluoromethyl)phenyl, pentafluorophenyl, 2-methoxyphenyl; X = S, O] has been reported. These new imidazolylidene NHCs I, bearing a (thio)urea function as a hydrogen bond donor promoted efficiently highly diastereoselective trans-cyclopentannulation of enals R1CH=CHCHO (R1 = n-Pr, Ph, naphthalen-2-yl, furan-2-yl, etc.) and enones R2CH=CHC(O)R3 (R2 = methoxycarbonyl, Ph, thiophen-2-yl, etc.; R3 = Ph, 2-phenylethenyl, thiophen-2-yl, etc.) in moderate to good yields (up to 69% yield) along with excellent enantioselectivity (up to 96% ee). This methodol. could be applied to a large variety of substrates (30 examples).
ChemCatChem published new progress about Amino alcohols, chiral Role: RCT (Reactant), RACT (Reactant or Reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Computed Properties of 3893-18-3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary