Wu, Qin; Xu, Genrui; Li, Weiqiang; Wan, Juan; Liu, Teng; Huang, Chao published the artcile< Cu(I)-Catalyzed and Base-Promoted [5 + 2 + 1] Cascade Cyclization of 2-Nitrochalcones with Aliphatic Primary Amines to 5H-Pyrimido[5,4-b]indole Frameworks>, Safety of 4-Bromobenzylamine, the main research area is nitrochalcone primary amine copper catalyst tandem cycloaddition; pyrimidoindole preparation.
An unprecedented [5 + 2 + 1] cascade cyclization to the preparation of 5H-pyrimido[5,4-b]indole derivatives was disclosed. The novel protocol of 2-nitrochalcones reacted with aliphatic primary amines catalyzed by CuI and promoted by Cs2CO3, which underwent a critical intermediate 2,3-disubstituted indole, providing structurally diverse 5H-pyrimido[5,4-b]indoles in generally high yields (77-90%) and broad substrate scopes (34 examples).
Organic Letters published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Safety of 4-Bromobenzylamine.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary