Wilson, Katy B.; Nedzbala, Hannah S.; Simpson, Spenser R.; Ericson, Megan N.; Westendorff, Karl S.; Chordia, Mahendra D.; Dickie, Diane A.; Harman, W. Dean published the artcile< Hydroamination of Dihapto-Coordinated Benzene and Diene Complexes of Tungsten: Fundamental Studies and the Synthesis of γ-Lycorane>, Recommanded Product: 4-Bromobenzylamine, the main research area is hydroamination dihapto benzene diene tungsten complex; gamma lycorane preparation; crystal mol structure dihapto alkene tungsten complex; arenes; cyclohexenes; dearomatization; dienes; hydroamination; lycorane; nitrosyl ligands; tungsten.
Reactions are described for complexes of the form WTp(NO)(PMe3)(η2-arene) and various amines, where the arene is benzene or benzene with an electron-withdrawing substituent (CF3, SO2Ph, SO2Me). The arene complex is first protonated to form an η2-arenium species, which then selectively adds the amine. The resulting η2-5-amino-1,3-cyclohexadiene complexes can then be subjected to the same sequence with a second nucleophile to form 3-aminocyclohexene complexes, where up to three stereocenters originate from the arene carbons. Alternatively, 1,3-cyclohexadiene complexes containing an ester group at the 5 position (also prepared from an arene) can be treated with acid followed by an amine to form trisubstituted 3-aminocyclohexenes. When the amine is primary, ring closure can occur to form a cis-fused bicyclic γ-lactam. Highly functionalized cyclohexenes can be liberated from the tungsten through oxidative decomplexation. The potential utility of this methodol. is demonstrated in the synthesis of the alkaloid γ-lycorane. An enantioenriched synthesis of a lactam precursor to γ-lycorane is also described. This compound is prepared from an enantioenriched version of the tungsten benzene complex. Regio- and stereochem. assignments for the reported compounds are supported by detailed 2D-NMR anal. and 13 mol. structure determinations (SC-XRD).
Helvetica Chimica Acta published new progress about Crystal structure. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Recommanded Product: 4-Bromobenzylamine.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary