Evans, P. Andrew; Oliver, Samuel published the artcile< Regio- and Enantiospecific Rhodium-Catalyzed Allylic Substitution with an Acyl Anion Equivalent>, Recommanded Product: 3-Bromo-5-methylbenzaldehyde, the main research area is chiral nonracemic tertiary allylic alc cyanohydrin pronucleophile allylic substitution; acyclic quaternary substituted aryl ketone stereoselective rhodium catalyzed preparation; cyanohydrin acyl anion equivalent stereoselective allylic alkylation pronucleophile.
The construction of enantiomerically enriched acyclic quaternary substituted ketones via the regio- and enantiospecific rhodium-catalyzed allylic alkylation reaction of chiral nonracemic tertiary allylic alcs. with cyanohydrin pronucleophiles is described. This approach provides an alternative method to the α-arylation and vinylation of acyclic disubstituted ketone enolates, which remains a challenging endeavor. The combination of the allylic alkylation with ring-closing metathesis facilitates the preparation of enantiomerically enriched 2,2-disubstituted naphthalene-1-ones, which have proven very difficult to prepare using a more conventional dearomatization strategy.
Organic Letters published new progress about Allylic alkylation catalysts, stereoselective. 188813-04-9 belongs to class bromides-buliding-blocks, and the molecular formula is C8H7BrO, Recommanded Product: 3-Bromo-5-methylbenzaldehyde.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary